Bronchospasm Associated With High Nitric Oxide

University of Sao Paulo

Status: Completed

Conditions: Airway Hyperresponsiveness; Asthma

Study type: Observational

Funder types: Other

Identifiers

NCT00666510

CAP125-01

Details and patient eligibility

About

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Full description

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Enrollment: 31 patients

Sex: All

Ages: 16 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion criteria

• hypertension, COPD, diabetes, pregnancy

Trial design

31 participants in 3 patient groups

Bronchospasm

Description:

Patients who presented bronchospasm during anesthesia induction

Asthma

Description:

Patients who presented bronchospasm during anesthesia induction and were identified as asthmatics

Control

Description:

Patients who were submitted to anesthesia induction and showed no complications