Brown Adipose Tissue in Type 1 Diabetes

Per-Ola Carlsson

Status: Completed

Conditions: Type1diabetes

Treatments: Radiation: Positron emission tomography with tracer 18F-deoxy glucose

Study type: Interventional

Funder types: Other

Identifiers

NCT02984514

Dnr 2015/191

Details and patient eligibility

About

Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.

In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adult patients (18 years of age or more)
2. Type 1 diabetes diagnose for more than 10 years

Exclusion criteria

1. Ongoing pregnancy
2. Ongoing breast-feeding
3. BMI<19
4. BMI >30
5. P-creatinine <110 µmol/l

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Type 1 diabetes

Experimental group

Description:

Positron emission tomography with tracer 18F-deoxy glucose

Treatment:

Radiation: Positron emission tomography with tracer 18F-deoxy glucose