Brown Fat Activity and Bariatric Surgery

Medical University of Vienna

Status: Completed

Conditions: Obesity

Treatments: Procedure: Bariatric Surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT03168009

1071/2017

Details and patient eligibility

About

The mechanisms of bariatric surgery-induced weight loss go beyond reductions in calorie intake and may involve several other pathways. Recently, brown adipose tissue (BAT) has been added as another potential player. Activation of BAT results in enhanced energy expenditure and promotes weight loss. Here, the investigators will study the effects of bariatric surgery on BAT function by PET/CT studies and molecular analyses of adipose biopsies. The investigators will explore different pathways that may affect BAT activation in this patient population.

Enrollment: 40 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 20 - 50 years
• Body mass index (BMI) 35 - 55kg/m2

Exclusion criteria

• Endocrine disease (except hyperlipidemia and substituted hypothyroidism or type 2 diabetes with fasting glucose concentrations <120mg/dl), kidney disease, inflammatory bowel disease, autoimmune or rheumatologic diseases that require immunosuppressive treatment, active oncologic disease, heart failure.
• Medication for any of the above mentioned conditions.
• Antibiotic treatment in the past three months
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Bariatric Surgery

Experimental group

Description:

Patients will undergo either Omega Loop Gastric Bypass or Sleeve Gastrectomy. The decision which type of surgery will be performed, will by made by the surgeon and the patient based on clinical considerations and the patient's wishes.

Treatment:

Procedure: Bariatric Surgery