Build-up of Action Representation in Autism Spectrum Disorders (ASD-BARN)

Civil Hospices of Lyon

Status: Completed

Conditions: Healthy; Autism Spectrum Disorder

Treatments: Other: Magnetoencephalography (MEG); Other: Behavioral assessments; Other: Magnetic Resonance Imaging (MRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT03108976

69HCL16_0677

Details and patient eligibility

About

Autistic spectrum disorders (ASD) are highly debilitating developmental syndromes which core feature is social and communications disorders. Motor skill impairments are frequently described in autism, but few studies have addressed the question of their origin and their specificity. Furthermore, it is not clear whether motor problems encountered in autism are related to dyspraxia, or if they present with specific features. This project aims at deciphering the origin of motor problems encountered by children who grow-up with autism in order to propose early interventions that could influence the other developmental trajectories, such as the social one.

Brain dynamics during sensori-motor learning is explored by applying magnetoencephalography (MEG) during the Bimanual Load-Lifting paradigm. Different motor processes namely: proprioceptive monitoring, use and update of a sensori-motor representation, anticipatory executive control will be correlated to brain oscillation modulation, both topographically and temporally. Two groups of children (aged between 7 and 12) are compared: a group of children with ASD and a control group of typically developing children.

Enrollment: 54 patients

Sex: All

Ages: 7 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Control group: children aged between 7 and 12
• Case group: children aged between 7 and 12 with a diagnostic of Autism Spectrum Disorders

Exclusion criteria

• Control group: presence of a neurological pathology, mental retardation or language and motor developmental delay
• Case group: presence of a neurological pathology, mental retardation

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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54 participants in 2 patient groups

Control group

Sham Comparator group

Description:

Children with a typical development.

Treatment:

Other: Magnetic Resonance Imaging (MRI)

Other: Behavioral assessments

Other: Magnetoencephalography (MEG)

Case group

Active Comparator group

Description:

Children with Autism Spectrum Disorders.

Treatment:

Other: Magnetic Resonance Imaging (MRI)

Other: Behavioral assessments

Other: Magnetoencephalography (MEG)