Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

Stanford University

Status: Enrolling

Conditions: Anesthesia; Adverse Effect; Cognitive Change; Cognitive Impairment; Anesthesia; Reaction; Cognitive Decline; Postoperative Delirium

Treatments: Combination Product: Neurocognition Interventions

Study type: Observational

Funder types: Other

Identifiers

NCT03839784

55169

Details and patient eligibility

About

The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be used to create a predictive model of periooperative neurocognitive disorders.

Enrollment: 250 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least 65 years old (inclusive)
• Non cardiac general elective surgery
• General anesthesia is expected for 2+ hours

Exclusion criteria

• Alzheimer's
• Dementia
• Parkinson's
• History of neurodegenerative diseases
• Medication for depression (ie. Benzodiazepines)
• Alcoholism
• Discretion of PI

Trial design

250 participants in 1 patient group

Neurocognitive Assessment Arm

Treatment:

Combination Product: Neurocognition Interventions