Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine

Cooper University Health Care

Status and phase

Enrolling

Phase 4

Conditions

Robotic Lung Surgery

Treatments

Drug: Intercostal nerve block and wound infiltration with liposomal bupivacaine

Drug: Intercostal nerve block and wound infiltration with bupivacaine/epinephrine + dexamethasone

Study type

Interventional

Funder types

Other

Identifiers

NCT03906617

18039

Details and patient eligibility

About

This study will assess analgesia after robotic lung surgery. Subjects will be randomized to receive wound infiltration and intercostal nerve block with either liposomal bupivacaine or bupivacaine/epinephrine + dexamethasone. Liposomal bupivacaine is a newer local anesthetic product and has not been compared to a combination of bupivacaine/epinephrine + dexamethasone in the context of pain control after robotic lung surgery.

Enrollment

34 estimated patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

undergoing robotic wedge resection or lobectomy for lung mass(es)

Exclusion criteria

emergency case
history of opiate abuse
chronic pain syndrome
intravenous drug use
chronic use of oral steroids
pregnancy
imprisonment
body weight lower than 70 kg
liver failure
uninsured patients
non-verbal patients or patients who are unable to rate their pain on a visual analogue pain scale
history of allergic reaction to any of the drugs used in the study: bupivacaine, liposomal bupivacaine, dexamethasone