C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease

Korea University

Status: Unknown

Conditions: NAFLD

Study type: Observational

Funder types: Other

Identifiers

NCT02083159

NAFLD(CTRP)

Details and patient eligibility

About

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.

Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.

The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.

Enrollment: 500 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20<age<80
• apparently healthy subjects

Exclusion criteria

• a history of CVD
• diabetes
• stage 2 hypertension
• malignancy
• severe renal or hepatic disease

Trial design

500 participants in 1 patient group

Patients with NAFLD