C677T Methylenetetrahydrofolate Reductase Mutation

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Mutation

Treatments: Other: infertily evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT05864937

PI2017_843_0045

Details and patient eligibility

About

To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation.

In this longitudinal retrospective study, patients with RM were treated during pregnancy with either: (i) 100 mg/day aspirin and 5 mg/day folic acid (group 1); or the same protocol plus 0.4 mg/day enoxaparin (group 2). An age-matched group of triparous women without RM or thrombophilia was used as the control group (group 3).

Full description

Recurrent miscarriage (RM) is defined as three or more consecutive spontaneous fetal losses and it affects 0.3% to 1% of pregnancies.To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation.

In this longitudinal retrospective study, patients with RM were treated during pregnancy with either: (i) 100 mg/day aspirin and 5 mg/day folic acid (group 1); or the same protocol plus 0.4 mg/day enoxaparin (group 2). An age-matched group of triparous women without RM or thrombophilia was used as the control group (group 3).

Enrollment: 363 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with three or more consecutive first-trimester miscarriage
• Three or more consecutive first-trimester miscatrriages
• C677T MTHFR gene mutation

Exclusion criteria

• Patients with the A1298C polymorphism