Caffeine, CYPA12 and Resistance Training

Alberto Pérez-López

Status: Enrolling

Conditions: CYP1A2 Polymorphism; Caffeine and Resistance Training

Treatments: Dietary Supplement: Caffeine and Resistance training; Dietary Supplement: Placebo and Resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT06610123

CEIP/2024/2/037_2

Details and patient eligibility

About

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the prolonged effects of caffeine on this type of exercise.

Objectives: The present study aims to analyze the prolonged effects of caffeine intake on neuromuscular adaptations to resistance training according to CYP1A2 polymorphism in men and women.

Enrollment: 48 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between ≥ 18 and ≤ 35 years.
• Body mass index (BMI) lowe than 25 kg/m².
• Physically active subjects (≥ 150 min/week of moderate exercise).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
• Participants capable of performing the tests.

Exclusion criteria

• History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
• Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
• Body mass index (BMI) ≥ 25 kg/m².
• Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
• Performing strenuous exercise within 48 hours prior to the tests.
• Failing to replicate the same food intake on the two experimental days.
• Consuming caffeine after 6 PM on the day prior to training or testing.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 8 patient groups, including a placebo group

Genotype AA - Male - Caffeine

Experimental group

Treatment:

Dietary Supplement: Caffeine and Resistance training

Genotype AC or CC - Male - Caffeine

Experimental group

Treatment:

Dietary Supplement: Caffeine and Resistance training

Genotype AA - Male - Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo and Resistance training

Genotype AC or CC - Male - Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo and Resistance training

Genotype AA - Female - Caffeine

Experimental group

Treatment:

Dietary Supplement: Caffeine and Resistance training

Genotype AC or CC - Female - Caffeine

Experimental group

Treatment:

Dietary Supplement: Caffeine and Resistance training

Genotype AA - Female - Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo and Resistance training

Genotype AC or CC - Female - Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo and Resistance training