Calcium-protein Co-ingestion and Gut Hormones

University of Bath

Status: Completed

Conditions: Diabetes; Obesity

Treatments: Dietary Supplement: Whey Protein Hydrolysate; Dietary Supplement: Milk Mineral Supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT03370497

REACH EP 16/17_164B

Details and patient eligibility

About

Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Rodent evidence suggests that calcium may potentiate the effects of protein ingestion on gut hormone secretion. Evidence in humans however, is lacking. This study aims to assess whether the addition of calcium to protein ingestion augments postprandial gut hormone availability in humans.

Enrollment: 6 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women age between 18-65 yrs.
• Able to consume provided supplement.
• Weight stable for the past 3 month (no change within 3%)

Exclusion criteria

• Any previous or current metabolic, cardio-pulmonary or musculoskeletal disease
• Not between the ages of 18-65 years
• A body mass index below 18.5 kg/m2 or above 30 kg/m2 (body mass (kg) divided by your height (m) squared)
• Taking medications that may influence your metabolism
• Plans to change your lifestyle (diet and/or physical activity) during the study period
• Not willing to refrain from alcohol containing drinks or unaccustomed exercise one day before the laboratory sessions.
• Current smoker

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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6 participants in 2 patient groups

Whey protein hydrolysate

Active Comparator group

Description:

Whey protein hydrolysate (50 g) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion.

Treatment:

Dietary Supplement: Whey Protein Hydrolysate

Whey protein hydrolysate plus milk mineral supplement

Experimental group

Description:

Milk mineral supplement (equating to 1000 mg calcium) plus whey protein hydrolysate (50 g) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion.

Treatment:

Dietary Supplement: Whey Protein Hydrolysate

Dietary Supplement: Milk Mineral Supplement