Calcium Retention as Influenced by Dietary Components That Induce an Acid Load

USDA Grand Forks Human Nutrition Research Center

Status: Completed

Conditions: Healthy

Treatments: Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet; Other: High Meat - High Potential Renal Acid Load (PRAL) diet

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00620763

IRB-2000707-013

GFHNRC087

Details and patient eligibility

About

The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein) can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.

Enrollment: 22 patients

Sex: Female

Ages: 40 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Average body mass index
• Normal blood work
• Normal bone density

Exclusion criteria

• Chronic disorder
• Non-traumatic bone fractures

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

A

Experimental group

Description:

Dietary Intervention: High meat and high acid load diet followed by low meat and low acid load diet

Treatment:

Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet

Other: High Meat - High Potential Renal Acid Load (PRAL) diet

B

Experimental group

Description:

Dietary Intervention: Low meat and low acid load diet followed by high meat and high acid load diet

Treatment:

Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet

Other: High Meat - High Potential Renal Acid Load (PRAL) diet