Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China

West China Second University Hospital

Status: Unknown

Conditions: Preeclampsia

Treatments: Drug: calcium

Study type: Interventional

Funder types: Other

Identifiers

NCT01806454

hx2ck1

Details and patient eligibility

About

the purpose of this study is to determine whether calcium supplementation is effective to prevent preeclampsia in Sichuang Province of china and which dose is more suitable

Enrollment: 11,000 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Nulliparity;age ≥35 years;Previous pre-eclampsia;Family history of pre-eclampsia;Multiple pregnancy;Time between pregnancies ≥10years;Body mass index ≥25;diastolic pressure ≥ 80 mm Hg before 20 weeks' gestation;Proteinuria ≥+ on more than one occasion or ≥ 300 mg/24 h before 20 weeks' gestation;Underlying medical conditions(Pre-existing hypertension;Pre-existing renal disease;Pre-existing diabetes;Presence of antiphospholipid antibodies;Chronic autoimmune disease);male sex partner's predecessor wife has Previous pre-eclampsia

Exclusion criteria

• first prenatal visit after 16 weeks' gestation;severe anemia;other Underlying medical conditions which need treatment first (such as uncontrolled hyperthyreosis )

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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11,000 participants in 2 patient groups

calcium A

Active Comparator group

Description:

tablets, 600mg per day,till birth

Treatment:

Drug: calcium

calcium B

Active Comparator group

Description:

tablets,1200mg per day,till birth

Treatment:

Drug: calcium