Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection

Beijing Tsinghua Chang Gung Hospital

Status: Completed

Conditions: To Predict Early Post-hepatectomy Mortality for HCC

Study type: Observational

Funder types: Other

Identifiers

NCT06621485

24467-4-01

Details and patient eligibility

About

Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma. The user-friendly tool with 6 preoperative predictors demonstrated excellent accuracy. The freely available calculator may help identify high-risk patients and reduce futile liver resection for hepatocellular carcinoma.

Enrollment: 4,966 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Adults (age ≥18 years) who underwent curative-intent hepatectomy for newly diagnosed HCC.

HCC diagnosis was confirmed histopathologically.

Exclusion criteria

Patients undergoing emergency hepatectomy for tumor rupture, as well as individuals with recurrent HCC, and those with missing survival data or less than 90 days of follow-up were excluded.

Trial design

4,966 participants in 2 patient groups

Training cohort

Description:

The training cohort was comprised of patients from 9 participating hospitals (First Hospital of Jilin University, Mengchao Hepatobiliary Hospital, the Fourth Hospital of Harbin, Pu'er People's Hospital, Liuyang People's Hospital, Ziyang First People's Hospital, First Affiliated Hospital of Shandong First Medical University \& Shandong Provincial Qianfoshan Hospital, First Affiliated Hospital of Harbin Medical University, and Fuyang People's Hospital).

Validation cohort

Description:

The validation cohort consisted of patients from the remaining two hospitals (Beijing Tsinghua Changgung Hospital and Eastern Hepatobiliary Surgery Hospital of Shanghai)