Calprotectin in Chronic Prosthetic Joint Infection

Technical University of Munich

Status: Enrolling

Conditions: Prosthetic Joint Infection; Prosthetic Infection; Arthroplasty Complications

Treatments: Diagnostic Test: Calprotectin Lateral Flow Test

Study type: Observational

Funder types: Other

Identifiers

NCT05060952

26/19 S-SR

Details and patient eligibility

About

A bacterial infection of an artificial joint is a serious complication that often requires additional surgery to exchange the arthroplasty. It is also difficult to recognize an infected joint, as the symptoms caused by the infection are very similar to those of other problems with arthroplasties, such as loosening of the implant. To improve the ability to diagnose prosthetic joint infections, this study compares the levels of calprotectin, a specific inflammatory protein, in the joint fluid of infected joints and joints with other complications. The underlying hypothesis is that the level of calprotectin in infected joints is significantly higher, thus facilitating the diagnosis of prosthetic joint infection.

Enrollment: 500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• scheduled arthroplasty exchange for any of the following reasons:
• infection
• loosening
• instability
• malalignment
• periprosthetic fracture

Exclusion criteria

• acute prosthetic joint infection

Trial design

500 participants in 2 patient groups

PJI

Description:

Patients with septic arthroplasty failure

Treatment:

Diagnostic Test: Calprotectin Lateral Flow Test

Aseptic

Description:

Patients with aseptic causes of arthroplasty failure

Treatment:

Diagnostic Test: Calprotectin Lateral Flow Test