Cambridge 7 Tesla Cerebral Small Vessel Disease Study (CamSVD)

University of Cambridge

Status: Enrolling

Conditions: Cerebral Small Vessel Diseases; Lacunar Stroke; Cerebral Small Vessel Ischemic Disease

Treatments: Other: Brief Memory and Executive Test; Diagnostic Test: 7 Tesla Magnetic Resonance Imaging

Study type: Observational

Funder types: Other

Identifiers

NCT04330222

A095132

Details and patient eligibility

About

CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.

We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.

Enrollment: 210 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Symptomatic lacunar stroke with corresponding lacunar infarct on MRI

Exclusion criteria

1. Unable/unwilling to consent;
2. Age<18;
3. Stroke aetiology due to cardio-embolism or large vessel disease;
4. Lacunar infarcts >1.5cm;
5. Severe stroke (NIHSS score ≥16);
6. Evidence of cortical infarct of any size;
7. Other major neurological diseases;
8. Severe systemic diseases such as heart failure, liver failure and kidney failure or any illness in the judgement of the investigator that could affect participation in the study;
9. MRI contraindications e.g. metal objects in or on the body, claustrophobia, pregnancy, known allergy to gadolinium containing contrast agent, impaired renal function with estimated glomerular filtration rate (eGFR) <59ml/min/1.73m2.

Trial design

210 participants in 2 patient groups

Patients with lacunar stroke due to SVD

Treatment:

Other: Brief Memory and Executive Test

Diagnostic Test: 7 Tesla Magnetic Resonance Imaging

Healthy stroke free volunteers

Treatment:

Diagnostic Test: 7 Tesla Magnetic Resonance Imaging