Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding? (GAINHIT)

University of Adelaide

Status: Terminated

Conditions: Insulin Resistance

Treatments: Other: High-fat overfeeding; Other: Modified HIT; Other: Wingate HIT

Study type: Interventional

Funder types: Other

Identifiers

NCT02177604

140319

Details and patient eligibility

About

Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.

Enrollment: 7 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week)
• Overweight (BMI 25-29.9 kg/m2)

Exclusion criteria

• Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.)
• History of chest pain (either at rest or during exercise.)
• Abnormal resting ECG at screening visit
• Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.)
• Blood pressure or blood lipids outside of reference ranges
• Serum ferritin <30ng/mL
• Uncontrolled asthma, current fever, or upper respiratory infection
• Current intake of > 140g alcohol/week
• Current smokers of cigarettes/cigars/marijuana
• Current intake of any illicit substance
• Experience claustrophobia in confined spaces
• Donated blood in the past 3 months
• Migraines
• Unable to comprehend study protocol
• Unable to perform exercise on a cycle ergometer at second screening visit

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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7 participants in 3 patient groups

Wingate HIT

Experimental group

Description:

7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.

Treatment:

Other: High-fat overfeeding

Other: Wingate HIT

Modified HIT

Experimental group

Description:

7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training

Treatment:

Other: High-fat overfeeding

Other: Modified HIT

No Exercise Control

Active Comparator group

Description:

7 days of high-fat overfeeding (50% excess calories) with no supervised exercise

Treatment:

Other: High-fat overfeeding