Can Genetic Markers Predict Weight Loss After Gastric By-pass Surgery

Karolinska Institute

Status: Completed

Conditions: Obesity

Treatments: Procedure: Gastric bypass or cholecystectomy

Study type: Observational

Funder types: Other

Identifiers

NCT01736384

2008/1010-31/3

Details and patient eligibility

About

There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.

Enrollment: 2,000 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• laparoscopic gastric by-pass with BMI greater than 35

Exclusion criteria

• unable to understand swedish

Trial design

2,000 participants in 1 patient group

Obesity

Description:

Gastric bypass surgery and non-obese controls undergoing cholecystectomy

Treatment:

Procedure: Gastric bypass or cholecystectomy