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Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?

The University of Texas System (UT) logo

The University of Texas System (UT)

Status

Completed

Conditions

Major Depressive Disorder
Mood Disorders

Treatments

Behavioral: Computerized self-help program for depression

Study type

Interventional

Funder types

Other

Identifiers

NCT01818453
2013-01-0025

Details and patient eligibility

About

The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.

Enrollment

500 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • English-speaking
  • Have reliable access to the internet (i.e., dialup or broadband access)
  • Be willing to donate saliva for DNA research
  • Have a current symptoms of depression
  • Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)

Exclusion criteria

  • Any diagnosis of a psychotic or bipolar disorder
  • Meeting for alcohol/drug dependence in the past year
  • Having current suicidal risk warranting crisis intervention

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

500 participants in 2 patient groups

Computerized self-help program for depression
Active Comparator group
Description:
Participants will have access to a computerized self-help program for depression, called deprexis, for 8 weeks.
Treatment:
Behavioral: Computerized self-help program for depression
Wait List Control
No Intervention group
Description:
Participants randomly assigned to a "wait list control" condition will wait 8 weeks after assignment before they can access the deprexis program.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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