Can MicroRNA's Predict Multicentricity in Breast Cancer?

Bezmialem Vakif University

Status: Completed

Conditions: Multicentric Breast Cancer

Treatments: Genetic: miRNA

Study type: Interventional

Funder types: Other

Identifiers

NCT04516330

MCBC-MIR

Details and patient eligibility

About

The aim of this study is to determine if microRNA's have role in predicting multicentricity in breast cancer. If a specific microRNA will be found to be related with multicentricity, it will help us to make appropriate decisions on the treatment of patients with multicentric breast cancer.

Full description

In the study that will be held at Bezmialem Vakif University Medical Faculty, General Surgery Department, 20 unifocal and 20 multifocal breast cancer patients will be included. Tissues will be taken from both tumoral and normal breast tissues and they will be saved in microRNA later solution under -80°C. Then, 84 microRNA's will be studied in these tissues to see if they express any of these microRNA's.

Enrollment: 57 patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Having breast cancer
2. Having no other malignancy
3. Female patient

Exclusion criteria

1. Having other malignancy
2. Under 18 years old
3. Male patient

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

57 participants in 2 patient groups

unifocal breast cancer

Active Comparator group

Description:

patients having unifocal breast cancer

Treatment:

Genetic: miRNA

multicentric breast cancer

Active Comparator group

Description:

patients having multicentric breast cancer

Treatment:

Genetic: miRNA