Can NAVA Mode Reduce Mechanical Ventilation Day in Patients With COPD ?

Fu Jen Catholic University Hospital

Status: Enrolling

Conditions: Obstructive Lung Diseases

Treatments: Device: Ventilator mode

Study type: Interventional

Funder types: Other

Identifiers

NCT05595733

FJUH110163

Details and patient eligibility

About

Background： Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume. At the same time, this mode can trigger and cycle-off inspiratory time by high sensitivity of electronic potential of diaphragm, increase patient-ventilator synchrony, reduce sedative drug, improve oxygenation, shorten mechanical ventilation day and reduce the rate of diaphragm atrophy. It can improve survival rate and hospital day of patients. Both the animal and human experiment have the effect of lung and diaphragm protection Effect： The results of this trial are expected to obtain electronic potential of diaphragm in patients with obstructive pulmonary disease. Reviewing the current literature, few related literatures have such data presentation. This trial hopes to evaluate whether the use of NAVA can reduce mechanical ventilation day by analyzing electronic potential of diaphragm in patients with obstructive pulmonary disease.

Investigators expect that participants with obstructive pulmonary disease using NAVA mode will have significantly less mechanical ventilation day than using conventional mode

Enrollment: 50 estimated patients

Sex: All

Ages: 20 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Obstructive pulmonary diseases include chronic obstructive pulmonary disease (COPD), asthma (Asthma), cystic fibrosis (cystic fibrosis), bronchiectasis (bronchiectasis), bronchiolitis or other diseases that cause airway stenosis, etc.
2. Other patients with obstructive pulmonary disease assessed by the clinical team
3. Consent signed by the principal or legal representative
4. Age > 20 years old and < 99 years old

Exclusion criteria

1. Those who cannot place a nasogastric tube due to medical conditions
2. Pregnant women
3. Those who have received gas cutting
4. Patients with phrenic nerve palsy
5. Neuromuscular disease
6. Intubation due to cardiac arrest

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

conventional group

No Intervention group

Description:

Using conventional mode to compare mechanical ventilation day with experimental group

experimental group

Experimental group

Description:

Using neurally adjusted ventilatory assist mode to compare mechanical ventilation day with conventional group

Treatment:

Device: Ventilator mode