Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?

Rigshospitalet

Status: Active, not recruiting

Conditions: Oropharyngeal Squamous Cell Carcinoma (OPSCC); Oropharynx Cancer; Oropharynx Cancer, Recurrent; Oropharynx Cancer, Metastatic; Oropharyngeal Carcinoma

Treatments: Diagnostic Test: Liquid biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT06592716

p-2023-15163 (Other Identifier)

H-23071576

Details and patient eligibility

About

This study investigates if longitudinal analyses of cell-free HPV-DNA in blood samples can be utilized to detect recurrence in patients diagnosed and treated for HPV-positive oropharyngeal squamous cell carcinoma.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with newly diagnosed HPV+ (and/or p16+) oropharyngeal squamous cell carcinoma
• Above 18 years of age
• Informed consent

Exclusion criteria

• The patient does not speak or understand Danish
• patients recieving palliative treatment

Trial design

200 participants in 1 patient group

Identify recurrence

Description:

The aim is to identify recurrence through longitudial analyses of circulating tumor HPV-DNA (ctHPV-DNA ) from blood samples.

Treatment:

Diagnostic Test: Liquid biopsy