Can VI-RADS/ADC Accurately Stage Bladder Cancer??

Mansoura University

Status: Active, not recruiting

Conditions: Bladder Cancer Stage; MRI Contrast Media Adverse Reaction; Bladder Cancer; Bladder Neoplasm; Diagnoses Disease; Bladder Urothelial Carcinoma; Bladder Disease

Treatments: Radiation: Multi-parametric MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT04167631

MANS.VI-RADS

Details and patient eligibility

About

Vesical Imaging-Reporting And Data System (VI-RADS) is proposed for predicting muscle invasive bladder cancer (MIBC) using multi-parametric MRI. However, No validation study on VI-RADS has been reported yet. Apparent diffusion coefficient (ADC) values on diffusion-weighted MRI are reportedly significantly lower in MIBC than those in non-MIBC(NMIBC).

Full description

Vesical Imaging-Reporting And Data System (VI-RADS) is proposed for predicting muscle invasive bladder cancer (MIBC) using multi-parametric MRI. However, No validation study on VI-RADS has been reported yet. Apparent diffusion coefficient (ADC) values on diffusion-weighted MRI are reportedly significantly lower in MIBC than those in non-MIBC(NMIBC).

We aim to examine the accuracy of VI-RADS for predicting MIBC in final histopathology specimen. To assess whether incorporating ADC into VI-RADS improves the MIBC predictive accuracy of VI-RADS

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed at the out-patient cystoscopy with papillary or small nodular bladder tumour

Exclusion criteria

• fungating lesions
• beyond the scope of enbloc resection

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

Multiparametric MRI

Other group

Description:

Vesical Imaging-Reporting And Data System (VI-RADS) using multi-parametric MRI.

Treatment:

Radiation: Multi-parametric MRI