Canadian Study of Prediction of Risk and Evolution to Dialysis, Death and Interim Cardiovascular Events Over Time (CanPREDDICT)

University of British Columbia

Status: Unknown

Conditions: Chronic Kidney Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00826319

H07-02457

Details and patient eligibility

About

This study will follow 2500 prevalent Chronic Kidney Disease (CKD) patients with Glomerular Filtration Rate (GFR) from 15-45 ml/min for 30 months with serial measurements every 6 months and subsequent annual chart review up to 60 months. This observational study will analyze the demographics, clinical status, medications and blood and urine samples of these patients and study the conventional biochemical, hormonal and metabolic parameters assessing which underlying biomarkers reflect the processes involved with disease progression.

Enrollment: 2,602 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients currently seen by a nephrologist, or referred for evaluation of CKD
• GFR between 15-45 ml/min
• Adults 19 years (depending on age of consent in province) or older
• At pediatric sites study participants will be eligible to participate at age 15 or older

Exclusion criteria

• Organ transplant recipient
• Life expectancy less than 12 months
• Acute Vasculitis
• Bioimpedance sub-study exclusion criteria:
• Amputation (readings are inaccurate)
• Any battery operated or electronic implanted device (such as pacemaker or implanted defibrillator - potential electrical hazard)
• Pregnant women

Trial design

2,602 participants in 3 patient groups

Bioimpedance sub-study cohort

Description:

Funded by a grant from Kidney Foundation of Canada, Dr. Catherine Clase initiated a bioimpedance sub-study across 7 centres and recruited n=416 within the CANPREDDICT population. The study uses bioimpedance measurements to assess volume status to determine the multivariable relationship between baseline volume overload and subsequent cardiovascular events. Subjects are followed at 6 months intervals for 2 years.

Ethnic enrichment cohort

Description:

Additional recruitment initiated and funded by the Principal Investigator, Adeera Levin for enriching the ethnic representation within the Canadian cohort on South Asian and Oriental Asian was completed from Sept 2012 to June 2013, n=53.

Original CanPreddict cohort

Description:

The original CanPreddict cohort was recruited from Jun 2008 - Oct 2009 has 2544 CKD patients across Canada.