Cancer Genetic Testing in Ethnic Populations

Mayo Clinic

Status

Enrolling

Conditions

Central Nervous System Carcinoma

Malignant Female Reproductive System Neoplasm

Digestive System Carcinoma

Carcinoma of Unknown Primary

Malignant Brain Neoplasm

Head and Neck Carcinoma

Malignant Musculoskeletal Neoplasm

Skin Carcinoma

Malignant Solid Neoplasm

Genitourinary System Carcinoma

Breast Carcinoma

Treatments

Procedure: Biospecimen Collection

Other: Genetic Testing

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT04475640

19-006717 (Other Identifier)

NCI-2020-04427 (Registry Identifier)

Details and patient eligibility

About

This clinical trial examines the integration of cancer genetic testing in various ethnic populations. Studying individuals and families at risk of cancer may help identify cancer genes and other persons at risk. The information from this study may provide an opportunity for cancer risk stratification and individualized screening in these ethnic populations.

Full description

PRIMARY OBJECTIVE:

I. To determine the prevalence of genetic mutations in cancer patients from various ethnic populations seeking care at Mayo Clinic Arizona and Mayo Clinic Florida cancer clinics.

SECONDARY OBJECTIVES:

I. Perform a chart review to assess the impact of genetic testing as part of standard of oncology care:

Ia. Determine prevalence of pathogenic germline mutation detected by multi-gene panel testing.

Ib. Determine differences in germline mutation detection in these patients as compared to traditional guideline (National Comprehensive Cancer Network [NCCN]) based approach for genetic evaluation.

OUTLINE:

Patients undergo collection of blood or saliva sample for genetic testing.

Enrollment

1,800 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients at least 18 years of age
Individuals diagnosed with any solid tumor cancer including, but not limited to, gastrointestinal, breast, gynecological, genitourinary, skin, central nervous system (CNS)/brain, head/neck, musculoskeletal or cancer of unknown primary; and presenting to Mayo Clinic (MC Arizona or MC Florida) for clinical management/treatment; and patients receive genetic testing as described above
Self-identified as being from various ethnic populations including Hispanic/Latino, Native American/Alaskan, African American (including of African descent), Asian and other European populations
Blood collection is feasible (health, access and/or tolerability) for requested blood sample(s)
Individuals have agreed to participate and signed the study informed consent form

Exclusion criteria

Patients who have had prior germline genetic testing involving a 40+ gene panel within the last 24 months at Mayo Clinic and available for review by the research coordinator at time of consent
Past or current history of hematological cancer (including leukemias, multiple myeloma)
All bone marrow transplants