Cancer Stem Cells in Acute Leukemia

Sanford Health

Status: Active, not recruiting

Conditions: Acute Leukemia

Treatments: Diagnostic Test: Bone marrow aspirate or peripheral blood sample collection

Study type: Observational

Funder types: Other

Identifiers

NCT03735797

SH Can Stem

Details and patient eligibility

About

Descriptive study of acute leukemia patients. Bone marrow aspirate or peripheral blood samples will be analyzed by next-generation sequencing for novel gene signatures and variations in transcriptional and epigenetic regulatory elements such as ARID5B and SALL4 variants.

Enrollment: 50 estimated patients

Sex: All

Ages: 1 month to 30 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly diagnosed or relapsed acute leukemia (AML or ALL)
• Plan to undergo diagnostic bone marrow aspirate or peripheral blood if clinically indicated (i.e. WBC>50,000 and bone marrow contraindicated)
• Age 1 month to 30 years
• Understand and provide informed consent (subject if>18, legal guardian if<18)

Exclusion criteria

• Age 0 to 4 weeks
• Treatment related leukemia or leukemia secondary to MDS
• Situations that would limit compliance with study requirements or ability to willingly give consent