Candidate Gene Association Study With Injury in Elite Male Youth Football Players

St Mary's University College

Status

Completed

Conditions

Injuries

Genetic Change

Treatments

Genetic: Genetic variants

Study type

Observational

Funder types

Other

Identifiers

NCT04952662

SMEC_2019-20_002

Details and patient eligibility

About

Understanding how candidate genes, previously associated with injury susceptibility, influence the incidence of muscle, bone, ligament, and tendon injuries across the development pathway of elite footballers may provide valuable insight into inherent injury predisposition to support the long-term development of every individual. Therefore, the aim of the present study was to investigate the association between candidate genetic variants and muscle, bone, ligament, and tendon injuries in elite football with sub-analysis of the influence of age and maturation on injury susceptibility.

Full description

Genetic variants in several candidate genes which code for structural constituents (COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722 and ACTN3 rs1815739), regulatory components (ACE rs1799752, ESR1 rs2234693 and MMP3 rs679620) and transcription factors (VDR rs2228570 and GDF5 rs143383) affecting the form, function and injury susceptibility of muscle, bone, ligament, and tendon tissue will be associated with overall injury, non-contact, bone, ligament, tendon and apophysitis injury risk in elite male youth and adult footballers.

Enrollment

123 patients

Sex

Male

Ages

8 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria