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Cangrelor in Patients With Acute Myocardial Infarction Undergoing PCI After CPR, Ventilated or Cardiogenic Shock (CAN-SHOCK)

I

IHF GmbH - Institut für Herzinfarktforschung

Status

Completed

Conditions

Acute Myocardial Infarction

Study type

Observational

Funder types

Other
Industry

Identifiers

NCT04611607
CAN-SHOCK

Details and patient eligibility

About

This registry will provide information about the efficacy and safety of cangrelor in a very high-risk group of patients with acute myocardial infarction undergoing PCI. It will not only include patients with cardiogenic shock, but a variety of patients not able to swallow tablets, such as those after CPR and/or with invasive or non-invasive ventilation. Therefore it will provide information about the use of cangrelor beyond the current knowledge.

Full description

This registry is a non-interventional, multicentre, retrospective cohort study in patients with acute myocardial infarction undergoing PCI after CRP, ventilated and/or with cardiogenic shock.

The study is purely observational; data will be documented retrospectively based on available medical records. No additional data will be collected, no study-related treatment will be initiated.

About 10 - 20 high-volume PCI clinics in Germany treating patients with myocardial infarction are eligible for participation. Participating sites will be given a maximum of 6 months for retrospectively documenting eligible patients.

Eligible are all patients with acute myocardial infarction (STEMI, NSTEMI) who underwent PCI after CRP, ventilated and/or with cardiogenic shock and were treated with cangrelor during index procedure. It is planned to enrol about 400 patients in total. Patient characteristics, procedural details and clinical events occurring during the period between index MI and discharge or death (whichever came first) will be documented based on the relevant existing medical charts of the patients.

Enrollment

303 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age ≥18 years
  • Acute Myocardial infarction (NSTEMI or STEMI)
  • PCI with stent implantation
  • Treatment with cangrelor during index procedure
  • At least one of the following criteria:
  • CPR prior to PCI
  • Cardiogenic shock
  • Heart failure with the need for mechanical or non-invasive ventila-tion

Exclusion criteria

No explicit medical exclusion criteria are stated to avoid selection bias.

Trial contacts and locations

10

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Data sourced from clinicaltrials.gov

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