Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

University of Minnesota (UMN)

Status

Enrolling

Conditions

Cannabidiol

Acute Stress Reaction

CBD

Stress

Treatments

Other: Stress Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT07069478

DMED-2025-33636

Details and patient eligibility

About

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Enrollment

125 estimated patients

Sex

All

Ages

21 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Adults who are relatively healthy and aged 21-70 years.
Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion criteria

Participated in previous acute stress studies that included a similar stress induction.
Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
Self-reported current pregnancy.
Self-reported current use of illicit substances (other than cannabis).
Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
Students of the principal researcher