Cannabis Reduction and Functional Outcomes

Medical University of South Carolina (MUSC)

Status: Begins enrollment in 1 month

Conditions: Cannabis Use Disorder

Treatments: Behavioral: CBT4CBT (Computerized Cognitive Behavioral Therapy); Behavioral: Contingency Management; Behavioral: Motivational Interviewing

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07218471

NIDA R01 DA062443 (Other Grant/Funding Number)

Pro00145652

Details and patient eligibility

About

This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in urinary cannabinoids. The study aims to assess improvements in cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life.

Enrollment: 176 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18+
• Urinary cannabinoid level ≥ 50 ng/mL
• DSM-5 diagnosis of CUD (mild, moderate, or severe)
• Willingness to attempt cannabis reduction
• Completion of Intake Visit

Exclusion criteria

• Serious medical/psychiatric conditions
• Pregnancy or breastfeeding
• Use of cannabis in past 30 days was for medical purposes only
• Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition
• TICS score ≤ 19

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)