Cantharone for the Treatment of Perenial Warts

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Wayne State University

Status and phase

Completed
Phase 4

Conditions

Wart, Genital

Treatments

Drug: Trichloroacetic Acid
Drug: Cantharidin

Study type

Interventional

Funder types

Other

Identifiers

NCT03625960
01551

Details and patient eligibility

About

Comparison of trichloroacetic acid versus cantharidine for the treatment of perenial warts.

Full description

Warts are one of the most common sexually transmitted diseases. They are caused by the human papilloma virus (HPV) that causes cervical cancer. Warts can grow, obstruct labor, and spread. Patients presenting to the obgyn clinic with perenial warts were randomized to treatment with trichloroacetic acid (one of the many types of treatments) or to the treatment with cantharidine group. Cantharidine is a vesicant extracted from beetle bugs which painlessly causes a small blister to form and cures the patient from the HPV infection causing the wart . We compared cosmesis, scar formation, pain and number of treatments (visits) as well as effectiveness in both groups. Objectives Determine if cantharone is more effective than trichloroacetic acid (TCA) for removal of warts Compare pain levels (pain during application) for each method Compare patient satisfaction for each method Compare scar formation and cosmesis for each method

Enrollment

12 patients

Sex

Female

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Warts on the perenial area
  • Less than 4mm across.

Exclusion criteria

  • Pregnancy
  • Less than 18 years old
  • Lesions larger than 4 millimeters across
  • Unclear diagnosis
  • Internal warts
  • Diabetes
  • HIV
  • Warts within 2 cm of mucosal areas

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

12 participants in 2 patient groups

Cantharidine group
Experimental group
Description:
Application of cantharidine to perenial warts
Treatment:
Drug: Cantharidin
trichloroacetic acid group
Active Comparator group
Description:
application of trichloroacetic acid to perenial warts
Treatment:
Drug: Trichloroacetic Acid

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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