Capnography Monitoring in Ventilated Children

Vincenzo Cannizzaro

Status: Unknown

Conditions: Heart Defects, Congenital; Lung Diseases, Interstitial; Lung Diseases, Obstructive; Child, Only; Critical Illness; ARDS, Human; Infant, Newborn, Diseases

Treatments: Diagnostic Test: capnography monitoring; Diagnostic Test: arterial blood gas

Study type: Observational

Funder types: Other

Identifiers

NCT04354220

KISPI-CAPNO

Details and patient eligibility

About

End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.

Full description

End-tidal and arterial CO2 measurements will be performed in invasively and non-invasively ventilated critically ill children. The endtidal CO2 values will assessed for their accuracy with respect to different underlying diseases and conditions of the children.

Enrollment: 178 patients

Sex: All

Ages: 1 hour to 13 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children on pressure controlled mechanical invasive or non-invasive ventilation on the Paediatric Intensive Care Unit of the University Children's Hospital Zurich
• Newborns with a birthweight of at least 2.0 kg
• Newborns with an age of at least 1 hour (age > 60 minutes)
• Children up to the last day of the 13th year of living
• Ability of care taker or patient to understand verbal and written instructions and the general consent or informed consent in German or English
• Obtained written general or informed consent as documented by signature
• Available arterial line, i.e. a specific catheter inserted in an artery

Exclusion criteria

• Care taker or participant unable for linguistic, mental or other reasons or unwilling to understand verbal or written information and to give written informed consent in German or English
• Care taker not available
• Newborns with a birthweight below 2.0 kg
• Newborns younger than 1 hour (age <60 minutes)
• Children with an age of 14 years onwards
• Missing arterial line
• Patients dependent on any other kind of respiratory support that is not compatible with the PcCO2-sensor or where a high leakage in the respiratory circuit makes PcCO2 measurements impossible (nasal mask ventilation, low-flow-/high-flow-ventilation, rebreathing mask, high- frequency-oscillation)
• Patients where the investigators act on the assumption that mechanical ventilation will be discontinued and/or the arterial line will be removed within 6 hours or where only one pair of values (arterial and endtidal CO2) can be compared
• Patients with a cyanotic shunt lesion with a weight of 15 kg or above

Trial design

178 participants in 4 patient groups

no shunt, no lung injury

Description:

ventilated newborns / infants / children with healthy lungs and without or corrected congenital heart disease and no intra-/extra-cardiac shunt

Treatment:

Diagnostic Test: arterial blood gas

Diagnostic Test: capnography monitoring

mild lung injury

Description:

ventilated newborns / infants / children with mild lung injury (OI between 4 and 8)

Treatment:

Diagnostic Test: arterial blood gas

Diagnostic Test: capnography monitoring

moderate-severe lung injury

Description:

ventilated newborns / infants / children with moderate or severe lung injury (OI above 8)

Treatment:

Diagnostic Test: arterial blood gas

Diagnostic Test: capnography monitoring

shunt lesion

Description:

ventilated newborns / infants / children with cyanotic heart diseases and therefore existing intra-cardiac or extra- cardiac right-left shunt lesions

Treatment:

Diagnostic Test: arterial blood gas

Diagnostic Test: capnography monitoring