Capsule Endoscopy or Mesenteric Angiogram in Patients With Overt Gastrointestinal Bleeding (GIB) of Obscure Origin

The Chinese University of Hong Kong logo

The Chinese University of Hong Kong

Status

Completed

Conditions

Gastrointestinal Hemorrhage

Treatments

Procedure: capsule endoscopy
Procedure: Mesenteric Angiogram

Study type

Interventional

Funder types

Other

Identifiers

NCT00153686
CE_Ang

Details and patient eligibility

About

To compare the diagnostic yield of mesenteric angiogram with CE in patients with active obscure GIB.

Full description

Gastrointestinal bleeding (GIB) of obscure origin is a common conditions resulting in recurrent hospitalization and extensive investigations. Mesenteric angiogram is one of the standard radiological investigations for GIB of obscure origin, and its diagnostic yield ranged from 40-80%. Capsule endoscopy (CE) is a newly available investigation for small bowel examination, especially in bleeding of obscure origin. The diagnostic yield is particularly high in patients with ongoing bleeding. This is a prospective randomized study to compare the diagnostic yield of mesenteric angiogram with CE in patients with overt GIB of obscure origin. The results will help to define the optimal management strategy for this group of patients.

Enrollment

58 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All patients admitted to PWH medical or surgical wards with melena or hematochezia in whom OGD and colonoscopy fail to identify site of bleeding.
  • Normal or non-diagnostic OGD and colonoscopy
  • Informed consent
  • Patients presented with shock will be resuscitated for urgent endoscopy

Exclusion criteria

  • Patients remained in shock despite resuscitation.
  • Moribund patients
  • Terminal malignancy
  • Presence of pacemaker or ICD
  • Suspected or confirmed intestinal obstruction
  • Swallowing difficulties
  • Renal failure that preclude angiographic examination
  • Pregnancy
  • Age <18
  • Refused consent

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

58 participants in 2 patient groups

Capsule Endoscopy
Experimental group
Description:
Capsule Endoscopy examination of small intestine
Treatment:
Procedure: capsule endoscopy
Mesenteric Angiogram
Other group
Description:
Mesenteric Angiogram of the small intestine
Treatment:
Procedure: Mesenteric Angiogram

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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