Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Danish Headache Center

Status: Completed

Conditions: Headache

Treatments: Drug: carbachol

Study type: Observational

Funder types: Other

Identifiers

NCT00357864

2006-002462-19

Details and patient eligibility

About

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Full description

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Enrollment: 15 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Aged 18-40
• 50-100 kg
• Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion criteria

• Tension type headache more than once/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 24 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease