Carbetocin Versus Oxytocin for Prevention of Postcesarean Hemorrhage in Pregnancy With High Risk for PPH

Rajavithi Hospital

Status and phase: Completed; Early Phase 1

Conditions: Cesarean Section; High Risk Pregnancy; Postpartum Hemorrhage

Treatments: Drug: Carbetocin; Drug: oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT04089176

T.Sopida

Details and patient eligibility

About

Objective: study efficacy of carbtocin versus oxytocin for prevention postpartum hemorrhage in high risk pregnancy who undergo cesarean section

Full description

Randomized controlled clinical trial. Defined patient in two group. Primary outcome is evaluate additional drug use Secondary outcome is evaluated estimated blood loss, hemoglobin level

Enrollment: 120 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• previous history of postpartum hemorrhage
• polyhydramnios
• fetal macrosomia
• previous cesarean section
• grand multiparity
• intramural myoma
• chorioamnionitis
• prolonged premature rupture of membrane
• augmentation of labour

Exclusion criteria

• pregnancy induce hypertension
• on anticoagulant
• placenta previa or placenta percreta

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 2 patient groups

protocal A

Active Comparator group

Description:

Carbetocin versus placebo

Treatment:

Drug: oxytocin

Drug: Carbetocin

protocal B

Active Comparator group

Description:

Oxytocin versus placebo

Treatment:

Drug: oxytocin

Drug: Carbetocin