Carbohydrates and Gut Hormones After Gastric Bypass Surgery

Hvidovre University Hospital

Status: Completed

Conditions: Overweight

Treatments: Other: Glucose + Fructose; Other: Sucrose; Other: Sucrose + Acarbose; Other: Isomaltulose

Study type: Interventional

Funder types: Other

Identifiers

NCT02879955

CM-CARB-16

Details and patient eligibility

About

To investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the effect of acarbose in gastric bypass operated subjects and BMI-matched controls.

Full description

Disaccharides such as sucrose or isomaltulose (also called palatinose) require digestion into monosaccharides (both are digested to glucose and fructose) by enzymes located in the brush border of the small intestine to be absorbed. The study will investigate the influence of carbohydrate digestion on gut hormone secretion.

Enrollment: 20 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Gastric bypass operated patients:

Inclusion Criteria:

• uncomplicated gastric bypass surgery performed minimum 12 months prior to study

Exclusion Criteria:

• Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM

Healthy control subjects:

Exclusion Criteria:

• Bariatric surgery or complicated upper abdominal surgery
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM
• Co-morbidities or medicine significantly affecting glucose metabolism or appetite regulation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

10 gastric bypass operated patients

Experimental group

Description:

4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.

Treatment:

Other: Sucrose + Acarbose

Other: Isomaltulose

Other: Glucose + Fructose

Other: Sucrose

10 healthy control subjects

Experimental group

Description:

4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.

Treatment:

Other: Sucrose + Acarbose

Other: Isomaltulose

Other: Glucose + Fructose

Other: Sucrose