Carbon Dioxide Insufflation Colonoscopy in IBD Patients

Vitkovice Hospital

Status: Completed

Conditions: Inflammatory Bowel Disease; Carbon Dioxide; Colonoscopy

Treatments: Procedure: Carbon dioxide insufflation

Study type: Interventional

Funder types: Other

Identifiers

NCT02563132

DDC VN 08

Details and patient eligibility

About

Carbon dioxide insufflation during colonoscopy significantly reduces discomfort (pain, bloating and flatulence) after the procedure. So far, it has not been studied in inflammatory bowel disease patients. The study was designed to evaluate discomfort after the carbon dioxide insufflation colonoscopy in comparison to standard air insufflation colonoscopy.

Full description

Carbon dioxide insufflation during colonoscopy significantly reduces discomfort (pain, bloating and flatulence) during up to 24 hours after the procedure. So far, it has not been studied in inflammatory bowel disease patients who represent specific patient population indicated for colonoscopy. They are characterized by younger age, structural changes of the colon including intestinal resections and need for repeated and frequently difficult procedures.The study was designed to evaluate discomfort during 24 hours after the carbon dioxide insufflation colonoscopy in comparison to standard air insufflation colonoscopy.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• known diagnosis of Crohn´s disease and ulcerative colitis
• indication for diagnostic colonoscopy
• informed consent
• unsedated or minimally sedated procedure (< 3 mg of midazolam)

Exclusion criteria

• planned incomplete or therapeutic procedure
• deep sedation or general anesthesia
• intestinal resection longer than ileocecal resection
• isolated gastroduodenal or jejunal location of Crohn´s disease (L4)
• ulcerative proctitis (E1)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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64 participants in 2 patient groups

Carbon dioxide insufflation colonoscopy (CO2)

Experimental group

Description:

Carbon dioxide during both insertion and withdrawal phase of the colonoscopy.

Treatment:

Procedure: Carbon dioxide insufflation

Air insufflation colonoscopy (AI)

No Intervention group

Description:

Air insufflation during both insertion and withdrawal phase of the colonoscopy.