Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow

Danish Headache Center

Status: Completed

Conditions: Headache Disorders

Treatments: Other: Carbon monoxide

Study type: Interventional

Funder types: Other

Identifiers

NCT03385174

H-17016387

Details and patient eligibility

About

Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.

Full description

In this study we will systematically investigate the headache-releasing properties of carbon monoxide as well as measure the effect of carbon monoxide on mean blood flow rate in the brain's large vessel with magnetic resonance imaging. These studies are important for understanding and further investigating the carbon monoxide's headache-releasing effect in healthy subjects.

Enrollment: 15 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Aged 18-50
• 50-100 kg

Exclusion criteria

• Tension type headache more than 5 dage /month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 24 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease
• Smoking
• Primary relatives with current or previous migraine

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Carbon monoxide

Other group

Description:

Each participant receives CO inhalation

Treatment:

Other: Carbon monoxide