Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Danish Headache Center

Status: Completed

Conditions: Migraine; Headache

Treatments: Other: Carbon monoxide; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02066558

H-3-2013-194

Details and patient eligibility

About

In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.

Full description

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.

With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.

Enrollment: 12 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Aged 18-50
• 50-100 kg

Exclusion criteria

• Tension type headache more than once/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 24 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease
• Smoking
• Primary relatives with current or previous migraine

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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12 participants in 2 patient groups, including a placebo group

carbon monoxide

Active Comparator group

Description:

Inhalation of carbon monoxide up to a carboxyhemoglobin concentration of 12% and 22%.

Treatment:

Other: Carbon monoxide

placebo

Placebo Comparator group

Description:

Atmospheric air

Treatment:

Other: Placebo