Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma

Kahramanmaraş Sütçü İmam University (KSU)

Status: Completed

Conditions: Triple Negative Breast Cancer; Carbonic Anhydrase IX

Treatments: Diagnostic Test: Carbonic anhydrase staining levels

Study type: Observational

Funder types: Other

Identifiers

NCT06309459

IRB 2023/04-34

Details and patient eligibility

About

Triple-negative breast carcinoma is characterized by the absence of estrogen receptors, progesterone receptors, and HER2/neu receptors. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. This study aimed to investigate CA IX expression in TNBC and its relationship with treatment effect.

Full description

Tru-cut biopsy materials, sent to our hospital pathology laboratory between August 2018 and May 2023, will be examined. Invasive carcinoma cases will be evaluated according to estrogen, progesterone, and HER 2 receptor levels. Triple-negative tumor cases were isolated and those cases who underwent breast resection in our hospital after receiving neoadjuvant chemotherapy (Adriamycin, cyclophosphamide, and then paclitaxel for 4 cycles) were included in the study.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Older than 18 years
• Triple-negative mastectomy cases
• Patients whose data can be available
• Patients who were operated in our hospital

Exclusion criteria

• Younger than 18 years
• Not triple negative mastectomy cases
• Patients with missing data
• Patients who were operated in another hospital

Trial design

40 participants in 2 patient groups

Low Staining

Description:

CA IX is a transmembrane protein, it exhibits cytoplasmic membrane staining. Immunohistochemically positive cells were graded as Low staining if they constituted \<10% of the total.

Treatment:

Diagnostic Test: Carbonic anhydrase staining levels

High Staining

Description:

CA IX is a transmembrane protein, it exhibits cytoplasmic membrane staining. Immunohistochemically positive cells were graded as high staining if they constituted ≥ 10%

Treatment:

Diagnostic Test: Carbonic anhydrase staining levels