Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

Roswell Park Comprehensive Cancer Center

Status: Enrolling

Conditions: E-Cig Use; Cigarette Smoking-Related Carcinoma

Treatments: Other: E-cigarette dependence Scale; Other: Effectiveness of different recruitment approaches; Other: Cannabis Engagement Assessment; Other: Choice of study completion locations

Study type: Observational

Funder types: Other

Identifiers

NCT07167225

I-4235024

Details and patient eligibility

About

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Full description

PRIMARY OBJECTIVE:

I. To evaluate differences in self-reported nicotine and cannabis use behaviors and biomarkers of exposure to toxicants and carcinogens by product use status, to generate effect sizes required to calculate sample sizes needed for a larger study.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Young adult (18-25 years old).
• Ability to read and write in English.
• Participants must fall into one of the following groups (based on self-report):
• Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.
• Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.
• E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly.
• No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).
• Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

Exclusion criteria

• Individuals under the age of 18 or over the age of 25.
• Currently pregnant or breastfeeding (female participants).
• Unwilling or unable to follow protocol requirements

Trial design

150 participants in 3 patient groups

E-cigarette consumers

Description:

Predominant e-cigarette consumers

Treatment:

Other: Choice of study completion locations

Other: Effectiveness of different recruitment approaches

Other: E-cigarette dependence Scale

Cannabis consumers

Description:

Predominant cannabis consumers

Treatment:

Other: Choice of study completion locations

Other: Cannabis Engagement Assessment

Other: Effectiveness of different recruitment approaches

e-cigarette -cannabis coconsumers

Description:

Consumers who use both e-cigarettes and cannabis .

Treatment:

Other: Choice of study completion locations

Other: Cannabis Engagement Assessment

Other: Effectiveness of different recruitment approaches

Other: E-cigarette dependence Scale