Cardiac Allograft Vasculopathy and Dobutamine Stress Echocardiography / Brain Natriuretic Peptide Coupling

University Hospital, Strasbourg, France

Status: Completed

Conditions: Allograft; Vasculopathy

Treatments: Procedure: Dobutamine stress echocardiography, coronarography, brachial arterial echography

Study type: Interventional

Funder types: Other

Identifiers

NCT00384540

3660

Details and patient eligibility

About

Primary purpose :To early detect cardiac allograft vasculopathy and to identify patients with high risk of cardiac events, by coupling the analysis of the kinetics of the brain natriuretic peptide ( BNP) with that of the left ventricle (LV) during a dobutamine stress echocardiography.

Hypothesis : Plasma BNP elevation and abnormalities of LV kinetic during the ESD, will be associated with the presence of allograft vasculopathy and the arisen of cardiovascular events.

Enrollment: 53 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Heart transplant recipients

Exclusion criteria

• No respect of inclusion criteria
• Pregnancy
• Severe renal failure (creatinin clearance < or equal to 30 ml/min)
• Dobutamine stress echocardiography contraindication

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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53 participants in 1 patient group

Cardiovascular events vs Dobutamine stress echocardiography

Other group

Treatment:

Procedure: Dobutamine stress echocardiography, coronarography, brachial arterial echography