Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

University Hospital Essen

Status: Enrolling

Conditions: Cardiac Amyloidosis; Mild Cognitive Impairment; Dementia, Alzheimer Type

Study type: Observational

Funder types: Other

Identifiers

NCT07154394

20-9291-BO

Details and patient eligibility

About

This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart.

The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia.

This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease
• No contraindications to undergo an MRI examination
• No contraindications to undergo an Amyloid PET scan

Exclusion criteria

• Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)
• Patients with pronounced cardiac preconditions
• Pregnant and breastfeeding women

Trial design

15 participants in 1 patient group

Patients referred for cerebral amyloid PET to clarify Alzheimer's disease

Description:

The study population consists of patients who have been clinically referred for a cerebral amyloid PET examination to clarify a diagnosis of Alzheimer's disease. The study population will undergo a comprehensive diagnostic evaluation, which includes: * An extension of the amyloid PET examination to include cardiac PET/MRI imaging. No additional substances are applied and there is no additional radiation exposure. * A transthoracic echocardiogram, including strain analysis * A 12-lead electrocardiogram (EKG)