Cardiac Amyloidosis in HFpEF Tunisian Patients (Amy-Card)

University Tunis El Manar

Status: Enrolling

Conditions: Cardiac Amyloidosis; Heart Failure With Preserved Ejection Fraction; Diagnosis; Prevalence; CMR; Echocardiography; Bone Scintigraphy

Study type: Observational

Funder types: Other

Identifiers

NCT06201832

13-2023

Details and patient eligibility

About

Cardiac amyloidosis (CA) has recently been reported as a common cause of heart failure with preserved left ventricular ejection fraction (HFpEF), with a prevalence of 6% in elderly HFpEF patients. However, the diagnosis of CA is still challenging and requires multiple costly investigations.

Regardless of the type of CA, TTR or AL, early diagnosis significantly improves prognosis.

In this study, the investigators aimed to determine the prevalence of CA in Tunisian HFpEF patients and to identify clinical and ultrasound criteria predictive of CA.

Enrollment: 87 estimated patients

Sex: All

Ages: 60 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HFpEF during the previous year
• IVS thickness of 12mm or greater

Exclusion criteria

• age under 60 years
• Acute coronary syndrome complicated by HFpEF
• Congenital heart disease