Cardiac Arrest and Ventilation Method

Seoul National University

Status: Completed

Conditions: Ventilation; Out-Of-Hospital Cardiac Arrest; Advanced Cardiac Life Support

Treatments: Device: Automatic Mechanical Ventilation; Device: Manual Ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT05550454

CAVE-I(P)

Details and patient eligibility

About

Comparison of Manual Ventilation and Automatic Mechanical Ventilation during CPR, Pilot & Feasibility Study (CAVE-I trial)

Full description

This is a preliminary randomized clinical trials comparing the effectiveness of the automatic mechanical ventilation method compared to manual ventilation methods commonly performed during advanced cardiac life support (ACLS) in emergency room for out-of-hospital cardiac arrest.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Out-of-hospital cardiac arrest (OHCA)
• Transferred by only EMS without prehospital return of spontaneous circulation (ROSC)
• ACLS for at least 20 minutes in the emergency room
• Arterial blood gas analysis at least once during ACLS

Exclusion criteria

• In-hospital cardiac arrest (IHCA)
• Not transferred by Emergency Medical Service
• ROSC gained before arriving at the ER
• OHCA caused by trauma
• ACLS is not performed for more than 20 minutes because the death is obvious
• Not able to intubate the trachea

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Automatic Mechanical Ventilation

Experimental group

Description:

Automatic Mechanical Ventilation during ACLS

Treatment:

Device: Automatic Mechanical Ventilation

Manual Ventilation

Active Comparator group

Description:

Standard care with manual ventilation, Ambu-bagging, during ACLS

Treatment:

Device: Manual Ventilation