Cardiac Function and Exercise Capacity in Pulmonary Arterial Hypertension (FONCE-HTAP)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Pulmonary Arterial Hypertension

Treatments: Behavioral: Rehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT02579954

2014-A00169-38 (Other Identifier)

1308156

Details and patient eligibility

About

Pulmonary Arterial Hypertension is characterized by a progressive increase in pulmonary vascular resistance inducing shortness of breath and exercise intolerance. We aim to correlate cardiac function (evaluated at rest by right heart catheterism and RMN) to exercise capacity (evaluated by endurance time at 75% of maximal workout), in prevalent patients with pulmonary arterial hypertension, and their evolution at three and twelve months.

Enrollment: 49 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Patients with Pulmonary Arterial Hypertension (idiopathic, heritable or due to anorexigens),
• Prevalent cases of pulmonary artery hypertension (≥ 6 months) confirmed by right heart catheterism,
• Stable for at least 3 months,
• Written consent.

Exclusion criteria

• Patients unable to proceed with six-minute walk test or CPET, or with contra-indication to exercise evaluation (syncope, low cardiac index, etc).
• Exercise induced abnormality (evaluated during the initial CPET) precluding to further evaluation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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49 participants in 2 patient groups

control group

No Intervention group

intervention

Experimental group

Description:

Rehabilitation

Treatment:

Behavioral: Rehabilitation