Cardiac Function and Morphology Evaluated by Magnetic Resonance Imaging in Growth Hormone Deficiency and Acromegaly

Herlev Hospital

Status: Completed

Conditions: Cardiac Function; Growth Hormone Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT00970463

KA-20060035

Details and patient eligibility

About

To test the hypothesis that both lack and excess of growth hormone (GH) is associated with cardiac abnormalities. Cardiac function and morphology will be evaluated by MRI before and after treatment.

Full description

It is an open prospective noninterventional clinical study. Treatment and follow-up will be according to usual guidelines, and will be unaffected by inclusion in the study. GHD patients will be treated with daily subcutaneous GH injections. Patients with acromegaly will be treated with either transsphenoidal surgery or by medical treatment with long acting somatostatin analogues, dopamine agonist, GH antagonist or combinations of these treatment modalities.

Patients will be examined by Cardiac MRI before treatment and after one year of treatment.

Enrollment: 22 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Peak GH below 6.0 ng/mL during Pyridostigmine-GHRH test.
• Nadir GH above 0.4 ng/mL and elevated levels of IGF-I during oral glucose tolerance test

Exclusion criteria

• Contraindications for magnetic resonance scan

Trial design

22 participants in 2 patient groups

GH

Description:

Patients with GHD

Pegvisomant and Somatostatin analogues

Description:

Acromegaly