Cardiac Magnetic Resonance for Early Detection of Chemotherapy or Radiation Therapy Induced Cardiotoxicity in Breast Cancer (CareBest)

Yonsei University

Status: Enrolling

Conditions: Chemotherapy Induced Cardiotoxicity

Treatments: Other: Cardiac magnetic resonance imaging

Study type: Observational

Funder types: Other

Identifiers

NCT03301389

4-2016-0730

Details and patient eligibility

About

Chemotherapy or radiation therapy-induced cardiotoxicity are well-recognized side effects in patients with cancer. The clinical significance of cardiotoxicity is growing with increasing cancer survivor-ship.

Left ventricular (LV) functional assessment is the standard of reference to diagnose chemotherapy- or radiation therapy-induced cardiotoxicity. The investigators will investigate the usefulness of T1 mapping parameters for early detection and prediction of chemotherapy-, radiation therapy-, or other therapy-induced cardiotoxicity in breast cancer patients This study aimed to achieve early detection of chemotherapy- or radiation therapy-induced cardiotoxicity using T1 mapping magnetic resonance imaging (MRI) and determine a prognostic imaging factor of chemotherapy- or radiation therapy-induced cardiotoxicity in patients treated for breast cancer.

Full description

Screening and follow-up cardiac magnetic resonance imaging (CMR) protocols for diagnosis of cardiotoxicity will be conducted in patients with breast cancer who have received or are planned to receive treatment for breast cancer. The protocol will include T1 and T2 mapping and cine imaging of the LV myocardium.

Enrollment: 2,000 estimated patients

Sex: Female

Ages: 17 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient with breast cancer

Exclusion criteria

• Contraindication of MRI
• Failure with informed consent
• Fail to scan screening protocol

Trial design

2,000 participants in 6 patient groups

Control group

Treatment:

Other: Cardiac magnetic resonance imaging

Pretreatment group

Description:

Patients in pretreatment state

Treatment:

Other: Cardiac magnetic resonance imaging

Anthracycline-based chemotherapy (3 months)

Description:

Patients who received anthracycline-based chemotherapy 3 months ago

Treatment:

Other: Cardiac magnetic resonance imaging

Anthracycline-based chemotherapy (6 months)

Description:

Patients who received anthracycline-based chemotherapy 6 months ago

Treatment:

Other: Cardiac magnetic resonance imaging

Anthracycline-based chemotherapy (more than 1 year ago)

Description:

Patients who received anthracycline-based chemotherapy more than 1 year ago

Treatment:

Other: Cardiac magnetic resonance imaging

Other therapy group

Description:

Patients who have been treated with other therapies (other chemo-therapies, combined radiation therapy, target agent therapy, hormone therapy)

Treatment:

Other: Cardiac magnetic resonance imaging