Cardiac Magnetic Resonance Imaging and Pulmonary Perfusion

Toulouse University Hospital

Status: Completed

Conditions: Pulmonary Hypertension

Treatments: Procedure: Magnetic resonance imaging (MRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT01100008

06 042 02

Details and patient eligibility

About

Pulmonary hypertension is a rare severe disease leading to cardiac insufficiency. Treatment depends on the severity of the disease.

This study evaluates cardiac MRI for the assessment of pulmonary hypertension severity and identification of parameters useful for the follow-up in order to adapt the medical treatment to status of the patient.

Evaluate if cardiac MRI can obviate right cardiac catheterization in the follow-up.

Full description

Thirty patients will be enrolled and followed for 1 year after their inclusion.

Cardiac MRI will be performed at inclusion and at 3 months and 12 months. At the same periods, echocardiography and right heart catheterization will be performed too.

Morphological and functional parameters will be studied with MRI and correlated to invasive parameters and echocardiography too.

Morphological parameters are: volumes, cardiac cavities areas and ratios and position of the interventricular septum. Functional parameters are: ejection fractions of right and left cavities, flow in pulmonary artery, across mitral and tricuspid valves, temporal measurements in the pulmonary artery and auriculoventricular valves.

The invasive measurements are considered as the gold standard for this study. The classification of the severity is defined according to the parameters from right cardiac catheterization (4 grades with severity increasing between 1 and 4).

Enrollment: 29 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults patients with pulmonary hypertension without specific treatment at inclusion
• Etiologies include chronic embolic disease, systemic fibrosis, Gougerot Sjogren, drug induced hypertension, primary hypertension.
• informed consent
• affiliated to medical insurance.

Exclusion criteria

• Left cardiac disease responsible for pulmonary hypertension, congenital cardiopathies
• Pulmonary functional tests with important impairment (decrease in TPCmore than 30%, decrease In VEMS more than 30%
• Child
• pregnancy
• contraindications to MRI
• without informed consent
• without insurance

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

29 participants in 1 patient group

Magnetic resonance imaging

Experimental group

Treatment:

Procedure: Magnetic resonance imaging (MRI)