Cardiac Magnetic Resonance Tomography for Heart Failure With Preserved Ejection Fraction

G

German Heart Institute

Status

Completed

Conditions

Heart Failure, Diastolic

Treatments

Diagnostic Test: CMR

Study type

Observational

Funder types

Other

Identifiers

NCT05322109
EA2/017/22

Details and patient eligibility

About

The diagnosis of heart failure with preserved ejection fraction has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function.However, it is still unclear which parameters can be used meaningfully for diagnostics.To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication for CMR and coronary angiography.

Full description

Heart failure with preserved pump function is a common disease that is associated with a high level of suffering for the patient. The diagnosis has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures. With its high spatial resolution and the possibility of tissue-specific diagnostics, cardiac MRI (CMR) offers outstanding possibilities in cardiac imaging without exposing the patient to ionizing radiation. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function. However, it is still unclear which parameters can be used meaningfully for diagnostics. There is evidence for a correlation with invasively increased LVEDP, although the number of patients examined in the previous studies was still small. In addition, possible influences from medication and clinical parameters were not examined. To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication. The significance of the study is that in the future CMR could supplement echocardiography in the diagnosis of HFpEF and further reduce the need for invasive diagnostics.

Enrollment

190 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients with CMR and left heart catheterization including LVEDP measurement within the same month

Exclusion criteria

  • Severe Valve Dysfunction or Pericardial/Pleural Disease
  • Contraindictaion for CR or Cath

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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