Cardiac MR (CMR) in Cardiac Resynchronization Therapy Non-responders

University Hospital Bonn (UKB)

Status: Terminated

Conditions: Heart Failure

Treatments: Device: CRT reprogramming (Medtronic CRT)

Study type: Interventional

Funder types: Other

Identifiers

NCT01367691

206/10

Details and patient eligibility

About

Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT.

Goals are to demonstrate that

• differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in myocardial activation
• differences in LV-RV pacing delays cause differences in LV/RV hemodynamics

and to use these data to optimize CRT.

Full description

CMR will be performed in patients under CRT who are currently not responding to CRT. Different LV-RV delays will be programmed during CMR and LV function and different dyssynchrony parameters will be assessed. Results will be used to determine the optimal LV-RV delay, and CRT-devices will be reprogrammed accordingly. Improvement in NYHA-class/conversion to therapy responder will be determined clinically after 3 months.

Enrollment: 1 patient

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• presence of CRT device
• CRT non responder

Exclusion criteria

• pregnancy
• end-stage renal failure

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)